Protein ubiquitination plays an important role in regulating the intracellular trafficking and turnover of cellular proteins within the cell. Defects have been implicated in both autoimmune diseases and cancer. E3 ligases are particularly important in this process because they recruit substrates to the ubiquitination machinery within the cell. Although many exist, our understanding of the different E3s and which cellular processes they can influence is limited. My research interests include characterizing the role of E3 ligases in cellular processes and understanding the contribution of E3 ligases to both autoimmunity and cancer.